A specific microbial consortium enhances Th1 immunity, improves LCMV viral clearance but aggravates LCMV disease pathology in mice

A specific microbial consortium enhances Th1 immunity, improves LCMV viral clearance but aggravates LCMV disease pathology in mice

Abstract Anti-viral immunity can vary tremendously from individual to individual but mechanistic understanding is still scarce. Here, we show that a defined, low complex bacterial community (OMM12) but not the general absence of microbes in germ-free mice leads to a more potent immune response compa...

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Main Authors: Daphne Kolland, Miriam Kuhlmann, Gustavo P. de Almeida, Amelie Köhler, Anela Arifovic, Alexandra von Strempel, Mohsen Pourjam, Silvia Bolsega, Christine Wurmser, Katja Steiger, Marijana Basic, Klaus Neuhaus, Carsten B. Schmidt-Weber, Bärbel Stecher, Dietmar Zehn, Caspar Ohnmacht
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59073-x
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https://doi.org/10.1038/s41467-025-59073-x

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