Biophysical properties of intrinsically disordered p130Cas substrate domain--implication in mechanosensing.

Biophysical properties of intrinsically disordered p130Cas substrate domain--implication in mechanosensing.

Mechanical stretch-induced tyrosine phosphorylation in the proline-rich 306-residue substrate domain (CasSD) of p130Cas (or BCAR1) has eluded an experimentally validated structural understanding. Cellular p130Cas tyrosine phosphorylation is shown to function in areas without internal actomyosin cont...

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Main Authors: Kinya Hotta, Soumya Ranganathan, Ruchuan Liu, Fei Wu, Hiroaki Machiyama, Rong Gao, Hiroaki Hirata, Neelesh Soni, Takashi Ohe, Christopher W V Hogue, M S Madhusudhan, Yasuhiro Sawada
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-04-01
Series:PLoS Computational Biology
Online Access:https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003532&type=printable
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https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003532&type=printable

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