Chronic Administration of DEN and 2-AAF for 13 and 18 weeks in Wistar Rats Leads to Progress of Hepatocarcinogenesis

Chronic Administration of DEN and 2-AAF for 13 and 18 weeks in Wistar Rats Leads to Progress of Hepatocarcinogenesis

Introduction and Objectives: Induction of hepatocellular carcinoma by administration of the agents diethylnitrosamine (DEN) and N-(2-Fluorenyl) acetamide (2-AAF) in murine animals, is a model to study liver cancer. The objective was to evaluate the alterations triggered by the chronic administration...

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Main Authors: Jaime Sánchez-Meza, Marina Campos-Valdez, José A. Domíngez-Rosales, Juliana M. Godínez-Rubí, Sarai C. Rodríguez-Reyes, Erika Matínez-López, Adriana M. Salazar-Montes, Carmen M. Gurrola Díaz, Manuel A. Castro-García, Guillermo M. Zúñiga-González, Laura V. Sánchez Orozco
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Annals of Hepatology
Online Access:http://www.sciencedirect.com/science/article/pii/S1665268125000948
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