Honokiol ameliorates reserpine-induced fibromyalgia through antioxidant, anti-inflammatory, neurotrophic, and anti-apoptotic mechanisms

Honokiol ameliorates reserpine-induced fibromyalgia through antioxidant, anti-inflammatory, neurotrophic, and anti-apoptotic mechanisms

Abstract Fibromyalgia (FM) is a chronic condition characterized by widespread musculoskeletal pain, fatigue, psychological disturbances, and sleep issues. Honokiol (HNK) is a bioactive compound known for its medicinal properties. This study evaluated HNK’s effectiveness in alleviating pain, depressi...

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Bibliographic Details
Main Authors: Suzan A. Khodir, Eman M. Sweed, Hala El-Haroun, Tarek H. Abd-Elhamid, Sara A. El Derbaly, Amany R. Mahmoud, Shaimaa M. Motawea
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Caspase-3
CGRP
Fibromyalgia
Honokiol
JAK/STAT3
Prostaglandin E2
Online Access:https://doi.org/10.1038/s41598-025-07209-w
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https://doi.org/10.1038/s41598-025-07209-w

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