Nanoparticle‐Delivered siRNA Targeting NSUN4 Relieves Systemic Lupus Erythematosus through Declining Mitophagy‐Mediated CD8+T Cell Exhaustion

Nanoparticle‐Delivered siRNA Targeting NSUN4 Relieves Systemic Lupus Erythematosus through Declining Mitophagy‐Mediated CD8+T Cell Exhaustion

ABSTRACT 5‐Methylcytosine modification (m5C) is an important posttranscriptional regulatory mechanism of gene expression. Exhausted CD8+T cells contribute to the development of many major diseases; however, their exact role and relationship to m5C in systemic lupus erythematosus (SLE) remain unknown...

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Main Authors: Bincheng Ren, Kaini He, Ning Wei, Shanshan Liu, Xiaoguang Cui, Xin Yang, Xiaojing Cheng, Tian Tian, Ru Gu, Xueyi Li
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:MedComm
Subjects:
CD8+T cell mitophagy and exhaustion
nanoparticle‐delivered siRNA
NSUN4
single‐cell RNA sequencing and m5C sequencing
systemic lupus erythematosus
Online Access:https://doi.org/10.1002/mco2.70311
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https://doi.org/10.1002/mco2.70311

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