CHARACTERISTICS OF SIGNALING PATHWAYS MEDIATING A CYTOTOXIC EFFECT OF DENDRITIC CELLS UPON ACTIVATED Т LYMPHOCYTES AND NK CELLS

CHARACTERISTICS OF SIGNALING PATHWAYS MEDIATING A CYTOTOXIC EFFECT OF DENDRITIC CELLS UPON ACTIVATED Т LYMPHOCYTES AND NK CELLS

Abstract. Cytotoxic/pro-apoptogenic effects of IFNα-induced dendritic cells (IFN-DCs) directed against Т-lymphocytes and NK cells were investigated in healthy donors. Using an allogenic MLC system, it was revealed that IFN-DCs induce apoptosis of both activated CD4+ and CD8+ T-lymphocytes, and NK ce...

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Bibliographic Details
Main Authors: T. V. Tyrinova, O. Yu. Leplina, M. A. Tikhonova, L. V. Sakhno, A. A. Ostanin, E. R. Chernykh
Format: Article
Language:Russian
Published: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 2014-07-01
Series:Медицинская иммунология
Subjects:
dendritic cells
trail
fasl
b7-h1/pd-1
т-lymphocytes
nk-cells, apoptosis
Online Access:https://www.mimmun.ru/mimmun/article/view/294
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https://www.mimmun.ru/mimmun/article/view/294

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