Early biodistribution and persistence of a protective live attenuated SIV vaccine elicits localised innate responses in multiple lymphoid tissues.

Early biodistribution and persistence of a protective live attenuated SIV vaccine elicits localised innate responses in multiple lymphoid tissues.

Vaccination of Mauritian cynomolgus macaques with the attenuated nef-truncated C8 variant of SIVmac251/32H (SIVmacC8) induces early, potent protection against pathogenic, heterologous challenge before the maturation of cognate immunity. To identify processes that contribute to early protection in th...

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Main Authors: Deborah Ferguson, Giada Mattiuzzo, Claire Ham, Richard Stebbings, Bo Li, Nicola J Rose, Edward T Mee, Deborah Smith, Mark Page, Martin P Cranage, Neil Almond, Greg J Towers, Neil J Berry
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0104390
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https://doi.org/10.1371/journal.pone.0104390

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