The Ferroptosis–Mitochondrial Axis in Depression: Unraveling the Feedforward Loop of Oxidative Stress, Metabolic Homeostasis Dysregulation, and Neuroinflammation

The Ferroptosis–Mitochondrial Axis in Depression: Unraveling the Feedforward Loop of Oxidative Stress, Metabolic Homeostasis Dysregulation, and Neuroinflammation

Emerging evidence links ferroptosis–mitochondrial dysregulation to depression pathogenesis through an oxidative stress–energy deficit–neuroinflammation cycle driven by iron overload. This study demonstrates that iron accumulation initiates ferroptosis via Fenton reaction-mediated lipid peroxidation,...

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Main Authors: Xu Liu, Qiang Luo, Yulong Zhao, Peng Ren, Yu Jin, Junjie Zhou
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Antioxidants
Subjects:
iron dysregulation
ferroptosis
depression
mitochondrial dysfunction
reactive oxygen species
lipid metabolism disorders
Online Access:https://www.mdpi.com/2076-3921/14/5/613
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