Pan-cancer copy number analysis identifies optimized size thresholds and co-occurrence models for individualized risk stratification

Pan-cancer copy number analysis identifies optimized size thresholds and co-occurrence models for individualized risk stratification

Abstract Chromosome instability leading to aneuploidy and accumulation of copy number gains or losses is a hallmark of cancer. Copy number alteration (CNA) signatures are increasingly used for cancer risk stratification, but size thresholds for defining CNAs across cancers are variable and the biolo...

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Main Authors: Minh P. Nguyen, William C. Chen, Kanish Mirchia, Abrar Choudhury, Naomi Zakimi, Vijay Nitturi, Tiemo J. Klisch, Stephen T. Magill, Calixto-Hope G. Lucas, Akash J. Patel, David R. Raleigh
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61063-y
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https://doi.org/10.1038/s41467-025-61063-y

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