Coordinated expression of retained introns and poison exons in renal cell carcinoma

Summary: The regulation and impact of tumor-specific isoforms in cancer is challenging to understand, with unclear links between oncogenic signaling and mRNA processing and decay. Using transcriptomic analyses and experimental validation, we demonstrate that clear cell renal cell carcinoma (ccRCC) t...

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Bibliographic Details
Main Authors: José C. Martínez, Mi Zhou, Gilbert Giri, Yi-Hsuan Tsai, Meghan M. Rowley, Grant A. Goda, Maria M. Aleman, William Y. Kim, Daniel Dominguez
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725007569
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