Enhanced IL-15-mediated NK cell activation and proliferation by an ADAM17 function-blocking antibody involves CD16A, CD137, and accessory cells

Enhanced IL-15-mediated NK cell activation and proliferation by an ADAM17 function-blocking antibody involves CD16A, CD137, and accessory cells

Background Natural killer (NK) cells are being extensively studied as a cell therapy for cancer. These cells are activated by recognition of ligands and antigens on tumor cells. Cytokine therapies, such as IL-15, are also broadly used to stimulate endogenous and adoptively transferred NK cells in pa...

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Main Authors: Jeffrey S Miller, Martin Felices, Shee Kwan Phung, Anders W Matson, Sam Wang, Ryan R Friess, Bruce Walcheck, Kate J Dixon, Jianming Wu, Rob Hullsiek, Anders J Lindstedt, Tanya S Freedman, Emily N Truckenbrod
Format: Article
Language:English
Published: BMJ Publishing Group 2024-07-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/7/e008959.full
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https://jitc.bmj.com/content/12/7/e008959.full

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