Downregulation of stromal syntenin sustains AML development

Downregulation of stromal syntenin sustains AML development

Abstract The crosstalk between cancer and stromal cells plays a critical role in tumor progression. Syntenin is a small scaffold protein involved in the regulation of intercellular communication that is emerging as a target for cancer therapy. Here, we show that certain aggressive forms of acute mye...

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Main Authors: Raphael Leblanc, Rania Ghossoub, Armelle Goubard, Rémy Castellano, Joanna Fares, Luc Camoin, Stephane Audebert, Marielle Balzano, Berna Bou‐Tayeh, Cyril Fauriat, Norbert Vey, Sylvain Garciaz, Jean‐Paul Borg, Yves Collette, Michel Aurrand‐Lions, Guido David, Pascale Zimmermann
Format: Article
Language:English
Published: Springer Nature 2023-10-01
Series:EMBO Molecular Medicine
Subjects:
cell‐to‐cell communication
syntenin
tumor aggressiveness
tumor–stroma
Online Access:https://doi.org/10.15252/emmm.202317570
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https://doi.org/10.15252/emmm.202317570

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