Navigating beyond the surface - prognostic significance of KRAS, NRAS, BRAF, PIK3CA, and TP53 mutations examined by exons

Navigating beyond the surface - prognostic significance of KRAS, NRAS, BRAF, PIK3CA, and TP53 mutations examined by exons

IntroductionMetastatic colorectal cancer (mCRC) is a disease with various molecular profiles that exhibit different evolution patterns. Although most mCRC patients receive the same chemotherapy drugs in the first-line setting, treatment response is heterogeneous suggesting some tumors are inherently...

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Main Authors: Vlad Adrian Afrăsânie, Mihai Vasile Marinca, Bogdan Gafton, Alexandra Rusu, Eliza Maria Froicu, Daniel Sur, Cristian Virgil Lungulescu, Raluca Cezara Popa, Irina Afrăsânie, Anca Viorica Ivanov, Georgiana Emmanuela Gîlcă-Blanariu, Lucian Miron, Cristina Rusu, Teodora Alexa-Stratulat
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Oncology
Subjects:
metastatic colorectal cancer
predictive biomarkers
prognostic biomarkers
KRAS
NRAS
BRAF
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1557609/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1557609/full

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