Symmetric adenine methylation is an essential DNA modification in the early-diverging fungus Rhizopus microsporus

Symmetric adenine methylation is an essential DNA modification in the early-diverging fungus Rhizopus microsporus

Abstract The discovery of N6-methyladenine (6mA) in eukaryotic genomes, typically found in prokaryotic DNA, has revolutionized epigenetics. Here, we show that symmetric 6mA is essential in the early diverging fungus Rhizopus microsporus, as the absence of the MT-A70 complex (MTA1c) responsible for t...

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Main Authors: Carlos Lax, Stephen J. Mondo, José F. Martínez, Anna Muszewska, Leo A. Baumgart, José A. Pérez-Ruiz, Pablo Carrillo-Marín, Kurt LaButti, Anna Lipzen, Yu Zhang, Jie Guo, Vivian Ng, Eusebio Navarro, Teresa E. Pawlowska, Igor V. Grigoriev, Francisco E. Nicolás, Victoriano Garre
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59170-x
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https://doi.org/10.1038/s41467-025-59170-x

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