The Slx4-Rad1-Rad10 nuclease differentially regulates deletions and duplications induced by a replication fork barrier.
Genome instability is a hallmark of cancer that can be caused by DNA replication stress. Copy number variation (CNV) is a type of genomic instability that has been associated with both tumorigenesis and drug resistance, but how these structural variants form in response to replication stress is not...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2025-05-01
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| Series: | PLoS Genetics |
| Online Access: | https://doi.org/10.1371/journal.pgen.1011720 |
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