Differential Effects of Hearing Loss Mutations in Homomeric P2X2 and Heteromeric P2X2/3 Receptors

Differential Effects of Hearing Loss Mutations in Homomeric P2X2 and Heteromeric P2X2/3 Receptors

P2X receptors are unspecific cation channels activated by ATP. They are expressed in various tissues and found in neuronal and immune cells. In mammals, seven subunits are described, which can assemble into homomeric and heteromeric trimers. P2X2 receptors play important roles in cochlear adaptation...

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Bibliographic Details
Main Authors: Paula-Luise Wand, Xenia Brünings, Debanjan Tewari, Stefanie Reuter, Ralf Mrowka, Klaus Benndorf, Thomas Zimmer, Christian Sattler
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Cells
Subjects:
P2X receptors
hearing loss mutations
fluorescent ATP
ligand-binding assay
patch-clamp
heteromeric ion channels
Online Access:https://www.mdpi.com/2073-4409/14/7/510
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