Genetic implication of GABAB receptors in the etiology of neurological and psychiatric disorders

Genetic implication of GABAB receptors in the etiology of neurological and psychiatric disorders

GABAB receptors (GBRs) are G protein-coupled receptors that mediate the actions of the inhibitory neurotransmitter GABA in the central nervous system. Early pharmacological studies with the GBR agonist baclofen and high-affinity antagonists were instrumental in revealing both pre- and postsynaptic f...

Full description

Saved in:
Bibliographic Details
Main Authors: Martin Gassmann, Michal Stawarski, Stylianos E. Antonarakis, Bernhard Bettler
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
GABBR1
GABBR2
AJAP1
PIANP
neurodevelopmental disorders
epileptic encephalopathy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1634128/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2025.1634128/full

Similar Items