A multi-omics approach reveals impaired lipid metabolism and oxidative stress in a zebrafish model of Alexander disease

A multi-omics approach reveals impaired lipid metabolism and oxidative stress in a zebrafish model of Alexander disease

Alexander disease (AxD) is a rare leukodystrophy caused by heterozygous mutations in the GFAP gene. To date, several in vitro and in vivo models have been generated in an attempt to unravel the main mechanisms underlying this complex disease. However, none of these models is suitable for investigati...

Full description

Saved in:
Bibliographic Details
Main Authors: Deianira Bellitto, Matteo Bozzo, Silvia Ravera, Nadia Bertola, Francesca Rosamilia, Jessica Milia, Paola Barboro, Gabriela Coronel Vargas, Donatella Di Lisa, Laura Pastorino, Francesca Lantieri, Patrizio Castagnola, Erika Iervasi, Marco Ponassi, Aldo Profumo, Kateryna Tkachenko, Camillo Rosano, Simona Candiani, Tiziana Bachetti
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Redox Biology
Subjects:
Neurodegeneration
Proteomics
Transcriptomics
Leukodystrophy
Astrocytes
GFAP
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725000576
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S2213231725000576

Similar Items