Clinical grade expansion protocol for the manufacture of thymus-derived Treg cells for clinical application
Abstract Background Adoptive transfer of regulatory T cells (Tregs) has provided promising results in treating autoimmune disorders, transplant rejection and graft versus-host disease in early clinical trials. However, major challenges remain for developing a standardized and robust good manufacturi...
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| Main Authors: | Giorgia Fanelli, Philippa Marks, Apoorva Aiyengar, Marco Romano, Sakina Gooljar, Sandeep Kumar, Michael Burch, Giovanna Lombardi |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-06-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-025-06561-9 |
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