Clinical grade expansion protocol for the manufacture of thymus-derived Treg cells for clinical application

Abstract Background Adoptive transfer of regulatory T cells (Tregs) has provided promising results in treating autoimmune disorders, transplant rejection and graft versus-host disease in early clinical trials. However, major challenges remain for developing a standardized and robust good manufacturi...

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Bibliographic Details
Main Authors: Giorgia Fanelli, Philippa Marks, Apoorva Aiyengar, Marco Romano, Sakina Gooljar, Sandeep Kumar, Michael Burch, Giovanna Lombardi
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Translational Medicine
Subjects:
Online Access:https://doi.org/10.1186/s12967-025-06561-9
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