Design, synthesis and biological evaluation of a novel class of indazole-containing compounds with potent anti-influenza activities targeting the PA-PB1 interface

Design, synthesis and biological evaluation of a novel class of indazole-containing compounds with potent anti-influenza activities targeting the PA-PB1 interface

The PA-PB1 interface of the influenza polymerase is an attractive site for antiviral drug design. In this study, we designed and synthesized a mini-library of indazole-containing compounds based on rational structure-based design to target the PB1-binding interface on PA. Biological evaluation of th...

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Bibliographic Details
Main Authors: Yun-Sang Tang, Chao Zhang, Jing Xu, Haibo Zhang, Zhe Jin, Mengjie Xiao, Nuermila Yiliyaer, Er-Fang Huang, Xin Zhao, Chun Hu, Pang-Chui Shaw
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Influenza
Anti-influenza compounds
Compound library synthesis
Lead discovery and optimization
Polymerase inhibitors
PA-PB1 inhibitors
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525002679
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