Rutaecarpine Protects Human Endothelial Cells from Oxidative-Stress-Induced Apoptosis via TRPV1- and AhR-Mediated Nrf2 Activation

Rutaecarpine Protects Human Endothelial Cells from Oxidative-Stress-Induced Apoptosis via TRPV1- and AhR-Mediated Nrf2 Activation

Endothelial cells play a crucial role in cardiovascular health by maintaining vascular homeostasis, regulating blood flow and vascular wall permeability, and protecting against external stressors. Oxidative stress, particularly excessive reactive oxygen species (ROS), disrupts cellular homeostasis a...

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Bibliographic Details
Main Authors: Chae Yeon Kim, Gi Ho Lee, Seung Yeon Lee, Anh Thi Ngoc Bui, Hye Gwang Jeong
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Antioxidants
Subjects:
rutaecarpine
endothelial dysfunction
oxidative stress
antioxidant enzymes
apoptosis
Online Access:https://www.mdpi.com/2076-3921/14/5/616
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