A Review of the Progress in the Development of Leishmaniasis Vaccines
Leishmaniasis is a parasitic infectious disease that accounts for approximately one million new cases annually. The treatment of this disease is complex and costly, particularly in developing countries. Numerous studies have been conducted on various vaccines utilizing live attenuated parasites, kil...
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Ardabil University of Medical Sciences
2024-07-01
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| Series: | Journal of Ardabil University of Medical Sciences |
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| Online Access: | http://jarums.arums.ac.ir/article-1-2399-en.pdf |
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| author | Narges Khaghanzadeh Fatemeh Javadi Afshin Samiei |
| author_facet | Narges Khaghanzadeh Fatemeh Javadi Afshin Samiei |
| author_sort | Narges Khaghanzadeh |
| collection | DOAJ |
| description | Leishmaniasis is a parasitic infectious disease that accounts for approximately one million new cases annually. The treatment of this disease is complex and costly, particularly in developing countries. Numerous studies have been conducted on various vaccines utilizing live attenuated parasites, killed parasites, subunit antigens, recombinant vaccines, and DNA technology. However, an effective and widely applicable preventive vaccine for leishmaniasis has not yet been developed. Present study aimed to examine the progress in the development of leishmaniasis vaccines.
Articles for this study were selected from the PubMed, Web of Science and Scopus databases using relevant keywords, focusing on subject matter, scientific quality, and publication date, with an emphasis on more recent publications.
Research on the development of leishmaniasis vaccines indicates that several candidates, such as Leishmune, CaniLeish, and Leish-Tec, which are at various stages of clinical trials, may serve as suitable options for controlling and preventing leishmaniasis in dogs. The LeishChim vaccine, designed using immunoinformatics and molecular docking techniques, has shown promising efficacy results in mouse studies. Additionally, the mutant gene-centered LmCen-/- vaccine has completed Phase 1 clinical trials in humans.
Given the importance of developing a leishmaniasis vaccine, research in this area continues. Utilizing immunoinformatics and biological modeling studies can aid in the faster identification of effective vaccine candidates. |
| format | Article |
| id | doaj-art-5e0d9c36453346e2852503e7967ee41e |
| institution | Kabale University |
| issn | 2228-7280 2228-7299 |
| language | fas |
| publishDate | 2024-07-01 |
| publisher | Ardabil University of Medical Sciences |
| record_format | Article |
| series | Journal of Ardabil University of Medical Sciences |
| spelling | doaj-art-5e0d9c36453346e2852503e7967ee41e2025-01-16T07:22:31ZfasArdabil University of Medical SciencesJournal of Ardabil University of Medical Sciences2228-72802228-72992024-07-01242129146A Review of the Progress in the Development of Leishmaniasis VaccinesNarges Khaghanzadeh0Fatemeh Javadi1Afshin Samiei2 Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran Student Research Committee, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran Leishmaniasis is a parasitic infectious disease that accounts for approximately one million new cases annually. The treatment of this disease is complex and costly, particularly in developing countries. Numerous studies have been conducted on various vaccines utilizing live attenuated parasites, killed parasites, subunit antigens, recombinant vaccines, and DNA technology. However, an effective and widely applicable preventive vaccine for leishmaniasis has not yet been developed. Present study aimed to examine the progress in the development of leishmaniasis vaccines. Articles for this study were selected from the PubMed, Web of Science and Scopus databases using relevant keywords, focusing on subject matter, scientific quality, and publication date, with an emphasis on more recent publications. Research on the development of leishmaniasis vaccines indicates that several candidates, such as Leishmune, CaniLeish, and Leish-Tec, which are at various stages of clinical trials, may serve as suitable options for controlling and preventing leishmaniasis in dogs. The LeishChim vaccine, designed using immunoinformatics and molecular docking techniques, has shown promising efficacy results in mouse studies. Additionally, the mutant gene-centered LmCen-/- vaccine has completed Phase 1 clinical trials in humans. Given the importance of developing a leishmaniasis vaccine, research in this area continues. Utilizing immunoinformatics and biological modeling studies can aid in the faster identification of effective vaccine candidates.http://jarums.arums.ac.ir/article-1-2399-en.pdfleishmaniasisvaccinecutaneous leishmaniasismucocutaneous leishmaniasisvisceral leishmaniasis |
| spellingShingle | Narges Khaghanzadeh Fatemeh Javadi Afshin Samiei A Review of the Progress in the Development of Leishmaniasis Vaccines Journal of Ardabil University of Medical Sciences leishmaniasis vaccine cutaneous leishmaniasis mucocutaneous leishmaniasis visceral leishmaniasis |
| title | A Review of the Progress in the Development of Leishmaniasis Vaccines |
| title_full | A Review of the Progress in the Development of Leishmaniasis Vaccines |
| title_fullStr | A Review of the Progress in the Development of Leishmaniasis Vaccines |
| title_full_unstemmed | A Review of the Progress in the Development of Leishmaniasis Vaccines |
| title_short | A Review of the Progress in the Development of Leishmaniasis Vaccines |
| title_sort | review of the progress in the development of leishmaniasis vaccines |
| topic | leishmaniasis vaccine cutaneous leishmaniasis mucocutaneous leishmaniasis visceral leishmaniasis |
| url | http://jarums.arums.ac.ir/article-1-2399-en.pdf |
| work_keys_str_mv | AT nargeskhaghanzadeh areviewoftheprogressinthedevelopmentofleishmaniasisvaccines AT fatemehjavadi areviewoftheprogressinthedevelopmentofleishmaniasisvaccines AT afshinsamiei areviewoftheprogressinthedevelopmentofleishmaniasisvaccines AT nargeskhaghanzadeh reviewoftheprogressinthedevelopmentofleishmaniasisvaccines AT fatemehjavadi reviewoftheprogressinthedevelopmentofleishmaniasisvaccines AT afshinsamiei reviewoftheprogressinthedevelopmentofleishmaniasisvaccines |