The Association Between IL‐8 Gene Polymorphisms and the Risk of Several Types of Cancer, Especially in Gastric Cancer
ABSTRACT Background Changes in functional genetic polymorphisms may increase or decrease the risk of cancer in patients. Nowadays, the association between polymorphisms in the interleukin‐8 (IL‐8) gene and the susceptibility of cancer risk have been investigated in many studies, however, above relat...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Cancer Reports |
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| Online Access: | https://doi.org/10.1002/cnr2.70103 |
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| author | Bin Xu Yidan Yan |
| author_facet | Bin Xu Yidan Yan |
| author_sort | Bin Xu |
| collection | DOAJ |
| description | ABSTRACT Background Changes in functional genetic polymorphisms may increase or decrease the risk of cancer in patients. Nowadays, the association between polymorphisms in the interleukin‐8 (IL‐8) gene and the susceptibility of cancer risk have been investigated in many studies, however, above relationships remain unclear. Aim The current study aims to comprehensively evaluate the association between IL‐8 gene six polymorphisms and the whole cancer risk, especially −251 polymorphism and gastric cancer. Methods and Results Six polymorphisms (−251, −353, +678, +1633, +2767, +781) were collected. The expression of serum IL‐8 was calculated by ELISA assay. First, 104 case–control studies were conducted. Second, this research has made significant discoveries regarding the −251, −353 and +781 polymorphisms and the potential associations with cancer risk. Finally, the serum IL‐8 levels in gastric cancer patients with AA/TT genotypes were significantly higher than those with the same genotypes of healthy controls and TT genotypes in gastric cancer patients. Conclusion Overall, the investigation has revealed that IL‐8 gene polymorphisms significantly influence vulnerability to cancer development, especially for gastric cancer. |
| format | Article |
| id | doaj-art-5e0161f596d24bd08bc42cfeccbd968e |
| institution | Kabale University |
| issn | 2573-8348 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj-art-5e0161f596d24bd08bc42cfeccbd968e2025-01-30T15:46:35ZengWileyCancer Reports2573-83482025-01-0181n/an/a10.1002/cnr2.70103The Association Between IL‐8 Gene Polymorphisms and the Risk of Several Types of Cancer, Especially in Gastric CancerBin Xu0Yidan Yan1Geriatrics Department Affiliated Hospital of Jiangnan University Wuxi ChinaMedical Oncology Affiliated Hospital of Jiangnan University Wuxi ChinaABSTRACT Background Changes in functional genetic polymorphisms may increase or decrease the risk of cancer in patients. Nowadays, the association between polymorphisms in the interleukin‐8 (IL‐8) gene and the susceptibility of cancer risk have been investigated in many studies, however, above relationships remain unclear. Aim The current study aims to comprehensively evaluate the association between IL‐8 gene six polymorphisms and the whole cancer risk, especially −251 polymorphism and gastric cancer. Methods and Results Six polymorphisms (−251, −353, +678, +1633, +2767, +781) were collected. The expression of serum IL‐8 was calculated by ELISA assay. First, 104 case–control studies were conducted. Second, this research has made significant discoveries regarding the −251, −353 and +781 polymorphisms and the potential associations with cancer risk. Finally, the serum IL‐8 levels in gastric cancer patients with AA/TT genotypes were significantly higher than those with the same genotypes of healthy controls and TT genotypes in gastric cancer patients. Conclusion Overall, the investigation has revealed that IL‐8 gene polymorphisms significantly influence vulnerability to cancer development, especially for gastric cancer.https://doi.org/10.1002/cnr2.70103biomarkercancer susceptibilitygastric cancerIL‐8polymorphism |
| spellingShingle | Bin Xu Yidan Yan The Association Between IL‐8 Gene Polymorphisms and the Risk of Several Types of Cancer, Especially in Gastric Cancer Cancer Reports biomarker cancer susceptibility gastric cancer IL‐8 polymorphism |
| title | The Association Between IL‐8 Gene Polymorphisms and the Risk of Several Types of Cancer, Especially in Gastric Cancer |
| title_full | The Association Between IL‐8 Gene Polymorphisms and the Risk of Several Types of Cancer, Especially in Gastric Cancer |
| title_fullStr | The Association Between IL‐8 Gene Polymorphisms and the Risk of Several Types of Cancer, Especially in Gastric Cancer |
| title_full_unstemmed | The Association Between IL‐8 Gene Polymorphisms and the Risk of Several Types of Cancer, Especially in Gastric Cancer |
| title_short | The Association Between IL‐8 Gene Polymorphisms and the Risk of Several Types of Cancer, Especially in Gastric Cancer |
| title_sort | association between il 8 gene polymorphisms and the risk of several types of cancer especially in gastric cancer |
| topic | biomarker cancer susceptibility gastric cancer IL‐8 polymorphism |
| url | https://doi.org/10.1002/cnr2.70103 |
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