Matrix‐Rigidity Cooperates With Biochemical Cues in M2 Macrophage Activation Through Increased Nuclear Deformation and Chromatin Accessibility

Matrix‐Rigidity Cooperates With Biochemical Cues in M2 Macrophage Activation Through Increased Nuclear Deformation and Chromatin Accessibility

Abstract Macrophages encounter a myriad of biochemical and mechanical stimuli across various tissues and pathological contexts. Notably, matrix rigidity has emerged as a pivotal regulator of macrophage activation through mechanotransduction. However, the precise mechanisms underlying the interplay b...

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Main Authors: Seung Jae Shin, Buuvee Bayarkhangai, Khaliunsarnai Tsogtbaatar, Meng Yuxuan, Sang‐Hyun Kim, Yong‐Jae Kim, Ali Taghizadeh, Daesan Kim, Dong‐Hwee Kim, Jung‐Hwan Lee, Jeongeun Hyun, Hae‐Won Kim
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Advanced Science
Subjects:
chromatin accessibility
macrophage activation
matrix rigidity
mechano‐chemical signaling
nuclear mechanosensing
Online Access:https://doi.org/10.1002/advs.202403409
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https://doi.org/10.1002/advs.202403409

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