Hydroxychloroquine reduces metastatic tumor burden in pancreatic adenocarcinoma through myeloperoxidase inhibition

Hydroxychloroquine reduces metastatic tumor burden in pancreatic adenocarcinoma through myeloperoxidase inhibition

Abstract Background Metastatic pancreatic adenocarcinoma has a 5-year survival of only 3%. Neutrophil extracellular traps are formed when neutrophils expel their intracellular contents and have been intricately linked to metastases. Hydroxychloroquine is an FDA-approved anti-malarial drug and neutro...

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Bibliographic Details
Main Authors: Britney Niemann, Pavan Rao, Quinn Hopen, Kaitlyn Landreth, Angisha Basnet, Werner Geldenhuys, Tracy W. Liu, Brian A. Boone
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Inflammation
Subjects:
Hydroxychloroquine
Myeloperoxidase
Pancreatic adenocarcinoma
Metastasis
Reactive oxygen species
Online Access:https://doi.org/10.1186/s12950-025-00456-8
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https://doi.org/10.1186/s12950-025-00456-8

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