Bacterial and host enzymes modulate the pro-inflammatory response elicited by the peptidoglycan of Lyme disease agent Borrelia burgdorferi.

Bacterial and host enzymes modulate the pro-inflammatory response elicited by the peptidoglycan of Lyme disease agent Borrelia burgdorferi.

The spirochete Borrelia burgdorferi causes Lyme disease. In some patients, an excessive, dysregulated proinflammatory immune response can develop in joints leading to persistent arthritis even after antibiotic therapy. In such patients, persistence of antigenic B. burgdorferi peptidoglycan (PGBb) fr...

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Main Authors: Joshua W McCausland, Zachary A Kloos, Irnov Irnov, Nicole D Sonnert, Junhui Zhou, Rachel Putnik, Elizabeth A Mueller, Allen C Steere, Noah W Palm, Catherine L Grimes, Christine Jacobs-Wagner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1013324
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https://doi.org/10.1371/journal.ppat.1013324

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