Therapeutic JAK inhibition does not impact lung injury during viral or bacterial pneumonia in male mice

Therapeutic JAK inhibition does not impact lung injury during viral or bacterial pneumonia in male mice

Abstract Influenza infections are often complicated by secondary bacterial infections such as MRSA pneumonia, which increase morbidity and mortality. Viral infections lead to an inflammatory response that includes elevated levels of IL‐6 and interferons. IL‐6 activates the JAK/STAT signaling pathway...

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Main Authors: Lokesh Sharma, Ravineel B. Singh, Caden Ngeow, Rick van derGeest, Alexis M. Duray, Nathanial J. Tolman, Bryan J. McVerry, Charles S. Dela Cruz, John F. Alcorn, William Bain, Keven M. Robinson
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Physiological Reports
Subjects:
bacteria super‐infection
influenza
JAK inhibition
methicillin‐resistant staph aureus
Online Access:https://doi.org/10.14814/phy2.70232
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https://doi.org/10.14814/phy2.70232

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