Th17 and effector CD8 T cells relate to disease progression in amyotrophic lateral sclerosis: a case control study

Th17 and effector CD8 T cells relate to disease progression in amyotrophic lateral sclerosis: a case control study

Abstract The immune system has garnered attention due to its association with disease progression in amyotrophic lateral sclerosis (ALS). However, the role of peripheral immune cells in this context remains controversial. Here, we conducted single-cell RNA-sequencing of peripheral blood mononuclear...

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Main Authors: Tatsuo Itou, Koji Fujita, Yuumi Okuzono, Dnyaneshwar Warude, Shuuichi Miyakawa, Yoshimi Mihara, Naoko Matsui, Hiroyuki Morino, Yusuke Kikukawa, Yuishin Izumi
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Neuroinflammation
Subjects:
Amyotrophic lateral sclerosis
Disease progression
Effector CD8 T cells
Interleukin-17A
Killer cell lectin-like receptor D1 (CD94)
Natural killer cells
Online Access:https://doi.org/10.1186/s12974-024-03327-w
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https://doi.org/10.1186/s12974-024-03327-w

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