Broad-spectrum coronavirus inhibitors discovered by modeling viral fusion dynamics

Development of oral, broad-spectrum therapeutics targeting SARS-CoV-2, its variants, and related coronaviruses could curb the spread of COVID-19 and avert future pandemics. We created a novel computational discovery pipeline that employed molecular dynamics simulation (MDS), artificial intelligence...

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Bibliographic Details
Main Authors: Charles B. Reilly, Joel Moore, Shanda Lightbown, Austin Paul, Sylvie G. Bernier, Kenneth E. Carlson, Donald E. Ingber
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Molecular Biosciences
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Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1575747/full
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