Network spreading and local biological vulnerability in amyotrophic lateral sclerosis

Network spreading and local biological vulnerability in amyotrophic lateral sclerosis

Abstract Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease that predominantly targets the motor system. Spread of pathology is thought to be driven by both local vulnerability and network architecture. Namely, molecular and cellular features may confer vulnerability to s...

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Main Authors: Asa Farahani, Justine Y. Hansen, Vincent Bazinet, Golia Shafiei, D. Louis Collins, Mahsa Dadar, Sanjay Kalra, Alain Dagher, Bratislav Misic
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08561-3
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https://doi.org/10.1038/s42003-025-08561-3

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