Causal role of the plasma lipidome in the occurrence and progression of chronic kidney disease: a two-sample Mendelian randomization study

Causal role of the plasma lipidome in the occurrence and progression of chronic kidney disease: a two-sample Mendelian randomization study

Abstract Objective This study aimed to utilize Mendelian randomization (MR) techniques to determine causal relationships between the plasma lipidome and the occurrence and progression of chronic kidney disease (CKD). Methods Summary statistics for 179 lipid species and six CKD-related phenotypes wer...

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Main Authors: Jiaming Su, Jiyuan Hu, Hongfang Liu, Yan Guo, Yang Shi, Yicheng Zheng, Zhaoxi Dong, Jiayou Liu, Zheyu Xu, Xinhui Yu, Jie Mei, Jing Peng, Lin Wang, Qingqing Liu
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Chronic kidney disease
Plasma lipidome
Lipid metabolism
Mendelian randomization
Causal inference
Online Access:https://doi.org/10.1186/s13098-025-01764-y
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https://doi.org/10.1186/s13098-025-01764-y

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