Deep and periventricular white matter hyperintensities exhibit differential metabolic profiles in arteriosclerotic cerebral small vessel disease: an untargeted metabolomics study

Deep and periventricular white matter hyperintensities exhibit differential metabolic profiles in arteriosclerotic cerebral small vessel disease: an untargeted metabolomics study

IntroductionAlthough white matter hyperintensities (WMH) are radiologically classified as deep WMH (DWMH) and periventricular WMH (PVWMH) based on spatial distribution, the distinct metabolic perturbations driving their pathogenesis remain incompletely characterized.MethodsThis study integrated unta...

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Main Authors: Shisheng Ye, Kaiyan Feng, Guofang Zeng, Jiaxin Cai, Lijuan Liang, Jiaxin Chen, Qishan He, Jianhui Mai, Qiaoling Wu, Chunwan Chen, Haifeng Huang, Li Yuan, Hai Chen, Yizhong Li, Hao Li, Xiong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Neuroscience
Subjects:
deep white matter hyperintensities
periventricular white matter hyperintensities
arteriosclerotic cerebral small vessel disease
untargeted metabolomics
weighted gene correlation network analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2025.1607242/full
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https://www.frontiersin.org/articles/10.3389/fnins.2025.1607242/full

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