Short-Term DMOG treatment rejuvenates senescent mesenchymal stem cells by enhancing mitochondrial function and mitophagy through the HIF-1α/BNIP3 pathway

Short-Term DMOG treatment rejuvenates senescent mesenchymal stem cells by enhancing mitochondrial function and mitophagy through the HIF-1α/BNIP3 pathway

Abstract Background Mesenchymal stem cells (MSCs) have potential for treating degenerative and immune diseases, but their clinical efficacy is limited by senescence, characterized by mitochondrial dysfunction, impaired mitophagy, and metabolic imbalance. The goal of this study was to investigate the...

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Main Authors: Jiaxin Wen, Lingxian Yi, Lei Chen, Jinhan Xu, Yanmin Zhang, Qiheng Cheng, Hangyu Ping, Huanyu Wang, Feng Shuang, Wei Chai, Tujun Weng
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells (MSCs)
Senescence
Hypoxia-Mimetic agent
HIF-1α
BNIP3
Mitophagy
Online Access:https://doi.org/10.1186/s13287-025-04422-2
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https://doi.org/10.1186/s13287-025-04422-2

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