Exosomes derived from hypoxic mesenchymal stem cell ameliorate premature ovarian insufficiency by reducing mitochondrial oxidative stress

Exosomes derived from hypoxic mesenchymal stem cell ameliorate premature ovarian insufficiency by reducing mitochondrial oxidative stress

Abstract Cyclophosphamide (CTX) exposure causes premature ovarian insufficiency (POI). The therapeutic potential of exosomes derived from human umbilical cord mesenchymal stem cells (hucMSCs) is not fully understood, especially regarding whether hypoxic preconditioning enhances their efficacy in POI...

Full description

Saved in:
Bibliographic Details
Main Authors: Shanshan Zhang, Xinfeng Zou, Xiaona Feng, Shuai Shi, Yanyun Zheng, Qun Li, Yanqun Wu
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Mesenchymal stem cells
Premature ovarian insufficiency
Exosomes
Reactive oxygen species
Hypoxic
Online Access:https://doi.org/10.1038/s41598-025-90879-3
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41598-025-90879-3

Similar Items