Berbamine attenuates hind limb ischemia-reperfusion injury by eliminating lipid ROS and inhibiting p65 nuclear translocation

Berbamine attenuates hind limb ischemia-reperfusion injury by eliminating lipid ROS and inhibiting p65 nuclear translocation

This research aims to explore whether Berbamine (BBM) can mitigate tissue damage in mice resulting from hind limb muscle ischemia-reperfusion by scavenging lipid ROS and inhibiting p65 nuclear translocation. The hind limb ischemia-reperfusion (IR) injury model in mice was employed. Forty-eight mice...

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Bibliographic Details
Main Authors: Lei Zheng, Biao Zhao, Run Ji, Zhenxi Zhang, Yutong Liu, Xiaoqi Zhao, Jing Cai, Tong Qiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
hind limb ischemia reperfusion injury
lipid ROS
p65
inflammation
muscle injury
antioxidant
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1509860/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1509860/full

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