53BP1 regulates p53-E2F7-dependent transcriptional gene repression and participates in the Fanconi anemia pathway

53BP1 regulates p53-E2F7-dependent transcriptional gene repression and participates in the Fanconi anemia pathway

Summary: p53-binding protein 1 (53BP1) participates in DNA damage repair through H4K20 di-methylation (H4K20me2)-mediated accumulation at DNA damage sites. However, it remains unclear whether H4K20me2-mediated 53BP1 chromatin binding regulates gene transcription in unstressed cells. Here, we demonst...

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Bibliographic Details
Main Authors: Yundong Fu, Wei Wu, Maosha Zhang, Zeming Rong, Bao Lin, Xin Zhou, Dingwei Li, Xin Shi, Jing Guo, Shuyun Ma, Qiang Chen
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
Subjects:
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725009234
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