Computational Design and Synthesis of Phthalimide Derivatives as TGF-β Pathway Inhibitors for Cancer Therapeutics

Computational Design and Synthesis of Phthalimide Derivatives as TGF-β Pathway Inhibitors for Cancer Therapeutics

Background: This study investigates the synthesis and pharmacological potential of <i>N</i>-substituted isoindoline-1,3-dione (phthalimide) derivatives. Using the M06 meta-GGA hybrid functional with a polarized 6-311G(d,p) basis set, computational evaluations assessed their impact on apo...

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Main Authors: Héctor M. Heras-Martínez, Blanca Sánchez-Ramírez, Linda-Lucila Landeros-Martínez, Víctor H. Ramos-Sánchez, Alejandro A. Camacho-Dávila, Kostiantyn O. Marichev, Alejandro Bugarin, David Chávez-Flores
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Chemistry
Subjects:
phthalimide derivatives
synthesis
cancer modulation
in silico
Online Access:https://www.mdpi.com/2624-8549/7/2/31
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