Integrative analysis of gene expression, protein abundance, and metabolomic profiling elucidates complex relationships in chronic hyperglycemia-induced changes in human aortic smooth muscle cells

Integrative analysis of gene expression, protein abundance, and metabolomic profiling elucidates complex relationships in chronic hyperglycemia-induced changes in human aortic smooth muscle cells

Abstract Type 2 diabetes mellitus (T2DM) is a major public health concern with significant cardiovascular complications (CVD). Despite extensive epidemiological data, the molecular mechanisms relating hyperglycemia to CVD remain incompletely understood. We here investigated the impact of chronic hyp...

Full description

Saved in:
Bibliographic Details
Main Authors: Smriti Bohara, Atefeh Bagheri, Elif G. Ertugral, Igor Radzikh, Yana Sandlers, Peng Jiang, Chandrasekhar R. Kothapalli
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Journal of Biological Engineering
Subjects:
Hyperglycemia
Biomechanics
Vascular smooth muscle cells
Diabetes
Gene expression
Transcriptomics
Online Access:https://doi.org/10.1186/s13036-024-00457-w
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s13036-024-00457-w

Similar Items