Cardiac Arrhythmia in a Patient with Sickle Cell Anemia and Falciparum Malaria Treated with Intravenous Artesunate
Treatment of severe malaria with artemisinin derivatives in patients with comorbid conditions such as sickle cell anemia must be considered with precaution. We report here a case of possibly undocumented ventricular arrhythmia in a sickle cell anemia patient diagnosed with Plasmodium falciparum mala...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2019/1913685 |
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| author | Abdulrahman Hummadi Sultan Mubarki Ayel yahay Awad Mohammed Al-Qahtani |
| author_facet | Abdulrahman Hummadi Sultan Mubarki Ayel yahay Awad Mohammed Al-Qahtani |
| author_sort | Abdulrahman Hummadi |
| collection | DOAJ |
| description | Treatment of severe malaria with artemisinin derivatives in patients with comorbid conditions such as sickle cell anemia must be considered with precaution. We report here a case of possibly undocumented ventricular arrhythmia in a sickle cell anemia patient diagnosed with Plasmodium falciparum malaria and treated with intravenous artesunate. The patient suffered from wide complex tachycardia after treatment with artesunate 170 mg (2.4 mg/kg) i.v. bolus, tachycardia was managed with amiodarone (150 mg i.v. for 10 minutes). Electrocardiographic abnormalities, including QT prolongation, are common in patients with sickle cell anemia. The mortality rate in sickle cell anemia patients due to cardiovascular and pulmonary complications remains high. The probability of precipitation of ventricular arrhythmias may increase in patients with sickle cell anemia, diagnosed with malaria and treated with artemisinin derivatives. |
| format | Article |
| id | doaj-art-5cf7ed227bfb4d89924f208d89a3a042 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-5cf7ed227bfb4d89924f208d89a3a0422025-02-03T06:00:37ZengWileyCase Reports in Infectious Diseases2090-66252090-66332019-01-01201910.1155/2019/19136851913685Cardiac Arrhythmia in a Patient with Sickle Cell Anemia and Falciparum Malaria Treated with Intravenous ArtesunateAbdulrahman Hummadi0Sultan Mubarki1Ayel yahay2Awad Mohammed Al-Qahtani3Internal Medicine and Endocrinology Consultant, Samtah General Hospital, Jizan, Saudi ArabiaKing Fahad Central Hospital, Jizan, Saudi ArabiaDepartment of Medicine, Hematology Division, King Khalid University, Abha, Saudi ArabiaDepartment of Family and Community Medicine, College of Medicine, Najran University, Najran, Saudi ArabiaTreatment of severe malaria with artemisinin derivatives in patients with comorbid conditions such as sickle cell anemia must be considered with precaution. We report here a case of possibly undocumented ventricular arrhythmia in a sickle cell anemia patient diagnosed with Plasmodium falciparum malaria and treated with intravenous artesunate. The patient suffered from wide complex tachycardia after treatment with artesunate 170 mg (2.4 mg/kg) i.v. bolus, tachycardia was managed with amiodarone (150 mg i.v. for 10 minutes). Electrocardiographic abnormalities, including QT prolongation, are common in patients with sickle cell anemia. The mortality rate in sickle cell anemia patients due to cardiovascular and pulmonary complications remains high. The probability of precipitation of ventricular arrhythmias may increase in patients with sickle cell anemia, diagnosed with malaria and treated with artemisinin derivatives.http://dx.doi.org/10.1155/2019/1913685 |
| spellingShingle | Abdulrahman Hummadi Sultan Mubarki Ayel yahay Awad Mohammed Al-Qahtani Cardiac Arrhythmia in a Patient with Sickle Cell Anemia and Falciparum Malaria Treated with Intravenous Artesunate Case Reports in Infectious Diseases |
| title | Cardiac Arrhythmia in a Patient with Sickle Cell Anemia and Falciparum Malaria Treated with Intravenous Artesunate |
| title_full | Cardiac Arrhythmia in a Patient with Sickle Cell Anemia and Falciparum Malaria Treated with Intravenous Artesunate |
| title_fullStr | Cardiac Arrhythmia in a Patient with Sickle Cell Anemia and Falciparum Malaria Treated with Intravenous Artesunate |
| title_full_unstemmed | Cardiac Arrhythmia in a Patient with Sickle Cell Anemia and Falciparum Malaria Treated with Intravenous Artesunate |
| title_short | Cardiac Arrhythmia in a Patient with Sickle Cell Anemia and Falciparum Malaria Treated with Intravenous Artesunate |
| title_sort | cardiac arrhythmia in a patient with sickle cell anemia and falciparum malaria treated with intravenous artesunate |
| url | http://dx.doi.org/10.1155/2019/1913685 |
| work_keys_str_mv | AT abdulrahmanhummadi cardiacarrhythmiainapatientwithsicklecellanemiaandfalciparummalariatreatedwithintravenousartesunate AT sultanmubarki cardiacarrhythmiainapatientwithsicklecellanemiaandfalciparummalariatreatedwithintravenousartesunate AT ayelyahay cardiacarrhythmiainapatientwithsicklecellanemiaandfalciparummalariatreatedwithintravenousartesunate AT awadmohammedalqahtani cardiacarrhythmiainapatientwithsicklecellanemiaandfalciparummalariatreatedwithintravenousartesunate |