Melbournevirus encodes a shorter H2B-H2A doublet histone variant that forms structurally distinct nucleosome structures

Abstract Unique among viruses, some giant viruses utilize histones to organize their genomes into nucleosomes. Melbournevirus encodes a distinct H2B-H2A histone doublet variant in addition to the canonical H4-H3 and H2B-H2A doublets. This viral histone variant has a truncated H2B portion and its ami...

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Bibliographic Details
Main Authors: Alejandro Villalta, Hugo Bisio, Chelsea M. Toner, Chantal Abergel, Karolin Luger
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62031-2
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