Deletions of <i>LPL</i> and <i>NKX3.1</i> in Prostate Cancer Progression: Game Changers or By-Standers in Tumor Evolution

Deletions of <i>LPL</i> and <i>NKX3.1</i> in Prostate Cancer Progression: Game Changers or By-Standers in Tumor Evolution

The tumor suppressor gene <i>NKX3</i>.1 and the <i>LPL</i> gene are located in close proximity on chromosome 8, and their deletion has been reported in multiple studies. However, the significance of <i>LPL</i> loss may be misinterpreted due to its co-deletion with...

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Main Authors: Tereza Vodičková, Mária Wozniaková, Vladimír Židlík, Jana Žmolíková, Jana Dvořáčková, Adéla Kondé, Jana Schwarzerová, Michal Grepl, Jan Bouchal
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomolecules
Subjects:
prostate cancer
LPL
NKX3.1
immunohistochemistry
FISH
whole-genome sequencing
Online Access:https://www.mdpi.com/2218-273X/15/6/758
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