Balancing between cuproplasia and copper-dependent cell death: molecular basis and clinical implications of ATOX1 in cancer

Abstract Human antioxidant protein 1 (ATOX1) is an essential regulator of copper homeostasis in cells. By interacting with other proteins involved in controlling the intracellular levels of cuprous ions (Cu+), ATOX1 contributes to the import, export, and subcellular distribution of Cu+ as it functio...

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Bibliographic Details
Main Authors: Justyna Suwara, Mariusz L. Hartman
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Online Access:https://doi.org/10.1186/s13046-025-03486-5
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