A new method for predicting essential proteins based on participation degree in protein complex and subgraph density.

A new method for predicting essential proteins based on participation degree in protein complex and subgraph density.

Essential proteins are crucial to living cells. Identification of essential proteins from protein-protein interaction (PPI) networks can be applied to pathway analysis and function prediction, furthermore, it can contribute to disease diagnosis and drug design. There have been some experimental and...

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Bibliographic Details
Main Authors: Xiujuan Lei, Xiaoqin Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0198998/1/pone.0198998.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210220%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210220T175550Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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