Formyl-methionine as a degradation signal at the N-termini of bacterial proteins

Formyl-methionine as a degradation signal at the N-termini of bacterial proteins

In bacteria, all nascent proteins bear the pretranslationally formed N-terminal formyl-methionine (fMet) residue. The fMet residue is cotranslationally deformylated by a ribosome-associated deformylase. The formylation of N-terminal Met in bacterial proteins is not strictly essential for either tran...

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Bibliographic Details
Main Authors: Konstantin I. Piatkov, Tri T. M. Vu, Cheol-Sang Hwang, Alexander Varshavsky
Format: Article
Language:English
Published: Shared Science Publishers OG 2015-09-01
Series:Microbial Cell
Subjects:
bacteria
formyl-methionine
degron
N-end rule
cotranslational degradation
Online Access:http://microbialcell.com/researcharticles/formyl-methionine-as-a-degradation-signal-at-the-n-termini-of-bacterial-proteins/
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http://microbialcell.com/researcharticles/formyl-methionine-as-a-degradation-signal-at-the-n-termini-of-bacterial-proteins/

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