Leucine enhances the cGAS-STING-NLRP3 pathway in autoimmune thyroiditis

Leucine enhances the cGAS-STING-NLRP3 pathway in autoimmune thyroiditis

Background: Branched-chain amino acids (BCAAs), including isoleucine (Ile), leucine (Leu), and valine (Val), are substrates for synthesising nitrogenous compounds and signalling molecules involved in regulating immunity. To date, data on the role of BCAAs in autoimmune thyroiditis (AIT) are lacking;...

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Bibliographic Details
Main Authors: Xin Shen, Tingting Feng, Shangbin Li, Xingxin Wang, Wenhui Zhang, Shouyan Wang, Xiaohan Zhang, Jiguo Yang, Yuanxiang Liu
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Translational Autoimmunity
Subjects:
Autoimmune thyroiditis
cGAS
Leucine
Mendelian randomisation
NLRP3
STING
Online Access:http://www.sciencedirect.com/science/article/pii/S258990902500019X
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