Nalbuphine as a Potential Alternative to Morphine in Sickle Cell Disease Patients with Vaso-occlusive Crisis: A Retrospective Cohort Study

Nalbuphine as a Potential Alternative to Morphine in Sickle Cell Disease Patients with Vaso-occlusive Crisis: A Retrospective Cohort Study

Background: The use of morphine in managing vaso-occlusive crisis (VOC) in patients with sickle cell disease (SCD) can result in significant side effects. Nalbuphine, a mixed agonist–antagonist opioid, may offer an alternative with fewer complications. Objective: To compare the efficacy and safety o...

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Main Authors: Mohannad Alghamdi, Mohamed Almulhim, Qasem Almulihi, Yousef A. Alhamaid, Mohammad Assiri, Abdullah Alzahid, Basmah Al Ghanim, Lama Albaish, Lama Alkhunaizi, Shahad Alali, Layan Alshehri
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-07-01
Series:Saudi Journal of Medicine and Medical Sciences
Subjects:
morphine
nalbuphine
opioid therapy
pain management
sickle cell disease
vaso-occlusive crisis
Online Access:https://journals.lww.com/10.4103/sjmms.sjmms_601_24
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