Bridging Mechanical Properties with Atomic Structures of Polymorphic α‐Synuclein Fibrils by Single‐Molecule Analysis and Molecular Dynamics Simulations

Bridging Mechanical Properties with Atomic Structures of Polymorphic α‐Synuclein Fibrils by Single‐Molecule Analysis and Molecular Dynamics Simulations

ABSTRACT α‐Synuclein (α‐syn) forms structurally distinct fibril polymorphs with various pathological activities in different subtypes of synucleinopathies, such as Parkinson's disease (PD). As a unique proteinaceous polymer, the mechanical property of α‐syn fibril is a primary determinant of it...

Full description

Saved in:
Bibliographic Details
Main Authors: Lulu Bi, Linge Li, Xiang Li, Shaojuan Wu, Xia Zhang, Yilin Zhao, Dan Li, Cong Liu, Zhonghuai Hou, Bo Sun
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Aggregate
Subjects:
molecular simulations
optical tweezers
Parkinson's disease
single molecule
α‐Syn fibril
Online Access:https://doi.org/10.1002/agt2.70023
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1002/agt2.70023

Similar Items