A HOTAIR-associated super-enhancer orchestrates glioblastoma malignancy via MEST

Abstract Glioblastoma (GBM) is one of the most malignant primary brain tumors, and factors governing its progression are not fully characterized. Recent research suggests that the long non-coding RNA (lncRNA) HOTAIR and super-enhancers (SEs) contribute significantly to GBM progression. Here, we perf...

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Main Authors: Peng Li, Yang Yang, Chunpeng Luan, Wenbin Wang, Yuan Jiang, Zhenhao Zhao, Bo Wang, Yuting Zhao, Yunlong Bai, Man Liu, Zhongfang Zhao, Lei Zhang, Yuyang Qian, Jiandang Shi
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-025-00551-8
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