CD19 -targeted CAR T therapy treating hematologic malignancies: hidden danger is the next neighbor to security?

CD19 -targeted CAR T therapy treating hematologic malignancies: hidden danger is the next neighbor to security?

CD19-targeted chimeric antigen receptor (CAR) T-cell therapy has achieved marvelous results in the treatment of patients with relapsed and/or refractory B-cell lymphomas, B-cell acute lymphoblastic leukemia, and multiple myeloma. As a new treatment method that has changed the existing treatment para...

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Bibliographic Details
Main Authors: Xueshuai Ye, Min Ge, Mengtian Tan, Yongqiang Wu, Haiqiang Zhang, Zexian Fu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
CD19
CAR T cancer therapy
cytokine release syndrome (CRS)
immune effector cell-associated neurotoxicity syndrome (ICANS)
secondary malignancies
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1490491/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1490491/full

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